Xarelto by Johnson & Johnson is Likely Another OverHyped Dud
Here we go again - another supposed blockbuster drug with issues but will get pushed through FDA anyway.
Date Created: May 23, 2012
Keywords: xarelto, FDA, clinical, trial, risk, blockbuster, johnson & johnson, johnson and johnson
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UPDATE: MAY 24, 2012
The FDA showed intelligence for a change and did not approve Xarelto for expanded use according to Yahoo Finance, " FDA panel votes against new use for J&J's Xarelto" The article contains additional information regarding the missing data of the outcome of a 15,000 patient clinical study. One of the FDA reviewers suggested that the missing data may indicate that Xarelto is not effective as J&J claims for expanded use in treating acute coronary syndrome.
Here we go again - another supposed blockbuster drug with issues but will get pushed through FDA anyway. Xarelto is a blood thinner used during major surgeries to reduce the risks of blood clots. It is now being pushed through FDA for regular use to reduce the risk of blood clots in people with acute coronary syndrome. However, due to missing data, " The staff appeared united in the view that the data did not prove Xarelto reduced the risk of death in patients with acute coronary syndrome..." according to Reuters.
In the same article, it is clearly stated that 12% of those in clinical trials dropped out. ANNNND - there were three deaths while on the drug that were excluded from information submitted to the FDA. Gee, what's this? If the people in the clinical trial DIE from the drug, they don't count? OMG. No wonder there are so many lawsuits against J&J...
According to the available FDA information, Xarelto was not demonstrated to be more effective than currently available drugs - AND has more side effects as well as higher cost.
Missing data, 12% dropout rate (or lost track of) and three deaths should be a sure sign that J&J knows there are issues with the drug. In addition, the expectation of such a large number of recipients to total over a billion in sales, although the drug should not be prescribed to those under 18, over 65, anyone with high blood pressure, etc, as well as the known and published side effects - um, how, exactly, could this be a 'blockbuster'? What I see is more off-label marketing to meet the sales goals and more harm with the resulting lawsuits. Oh, joy. Higher health care costs to pay for yet another 'blockbuster'. More like 'economy buster'.
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1. Associated Press (2012, May 23). FDA panel votes against new use for J&J's Xarelto. Yahoo Finance. Retrieved from http://finance.yahoo.com/news/fda-panel-votes-against-j-210934750.html;_ylt=A0LEV1OMeRpU81sAuWNXNyoA;_ylu=X3oDMTEzNWxlYWFhBHNlYwNzcgRwb3MDNwRjb2xvA2JmMQR2dGlkA1NNRTU4OV8x
2. Anna Yukhananov (2012, May 21). FDA staff sends mixed message on J&J drug Xarelto. Reuters. Retrieved from http://www.reuters.com/article/2012/05/21/us-fda-johnson-xarelto-idUSBRE84K0M220120521?feedType=RSS&feedName=healthNews&utm_source=twitterfeed&utm_medium=twitter&utm_campaign=Feed%3A+reuters%2FhealthNews+%28Reuters+Health+News%29
3. Xarelto Insert (2014, August 28). Xarelto. Drugs.com. Retrieved from http://www.drugs.com/pro/xarelto.html
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JNJ to Remove Harmful Chems from Baby Care by 2013 and Adult Care by 2015 What are consumers to use until harmful chems are removed?
The Extremely Expensive Problems Facing Johnson & Johnson If you think Alex Gorsky is the solution to the problems facing JNJ, you haven't kept up with the JNJ drama over the years. Stop in and get a clue...
Johnson & Johnson Pacifies Shareholders with Pathetic $23 Million Shareholders filed a lawsuit against JNJ in December of 2010. Three years later, Johnson & Johnson pacified shareholders with a pathetic $23 million settlement without having to admit to wrongdoing.
Xarelto by Johnson & Johnson is Likely Another OverHyped Dud Here we go again - another supposed blockbuster drug with issues but will get pushed through FDA anyway.
Ingredients to avoid: Methylisothiazolinone and Methylchloroisothiazolinone Two more ingredients to keep an eye on. Emerging data suggests this one may be a dermal irritant, associated with eczema and a possible neurotoxin.
Johnson & Johnson Delaying $2.2 Billion DOJ Settlement to Reduce Risk of Liability to States and Victims Johnson & Johnson wants to settle to avoid court and not have to admit to doing anything wrong. However, the lifelong health problems facing their victims should be paid for by Johnson & Johnson, not taxpayers.
Johnson & Johnson Retired CEO Weldon Gets $143.5 M for Retirement, $1 M Salary and Bonuses? Okayyy, how about the high cost of healthcare? R&D? Yeah, right.
Lawsuits Mounting for Harm by Johnson & Johnson Implanted Mesh Products J&J started using a mesh product for organ prolapse, such as bladder and uterous. However, the consequences of this option increases risks of harm to other internal organs.
Facts About Johnson and Johnson Bill Weldon CEO Successor Alex Gorsky Alex Gorsky has his illegal little paws in a whole lot of J&J issues, from Omnicare kickbacks, Medicaid fraud, defective hips and the latest addition, the Mesh Mess.
Johnson & Johnson Risperdal: Broken Laws and Side Effects Lies, bribes, kickbacks, truthtwisting, omissions and more regarding Risperdal. Just another day at J&J.
Johnson and Johnson DePuy Global Recall of 93,000 Defective All-Metal Hips The DePuy subsidiary of Johnson & Johnson faces dealing with the recall of 93,000 metal on metal hips for high failure rate and metal poisoning for the recipients. The worst part is that they knew there was a problem and kept selling the hips anyway.
Johnson & Johnson Credo Analysis The Johnson & Johnson Credo sounds good, but is nothing more than a fairy tale since it certainly is not used as a guide for ethical business decisions.
Women Request US Attorney General Investigate Johnson & Johnson CEO Alex Gorsky A judge agreed that records regarding Johnson & Johnson vaginal mesh were lost and destroyed since as far back as 2007. Alex Gorsky was head of medical devices and may be covering up corruption that radiates through the entire company as well as the US Food and Drug Administration.
Johnson & Johnson: The Global Lawsuit Company Global lawsuits range from defective hips, pelvic mesh, shareholders to price-fixing, and more. JNJ has legal woes all over the planet.
Johnson & Johnson Paying Outrageous Salaries Amid Massive Layoffs, Plant Closings and Facility Deterioration Irresponsibility at J&J allows facilities to deteriorate - putting consumers at risk of harm, plants shut down by FDA for violations resulting in massive layoffs - but continued outrageous salaries such as $30 million for 2011 and $145 million retirement fund for CEO Bill Weldon - financially draining US healthcare.
The High Cost to EVERY American of Corruption at Johnson & Johnson J&J has only *one* source of income: your wallet. The DOJ has only *one* source of income: your wallet. So, our wallets buy the products, pay insurance companies, pay to prosecute J&J, pay to defend J&J and then pay the fines. Everybody say: NO MORE! (tears)
Johnson & Johnson UN-health Care If people were healthy, Johnson & Johnson would go broke. Carcinogens in consumer goods, medical devices with known long-term health consequences, in addition to drugs with side effects that require more drugs, help ensure that J&J remains profitable.
Johnson and Johnson Appears to Have More Lawsuits than Drugs in Their Pipeline The number of lawsuits against Johnson & Johnson continues to grow. Everything from faulty hips to baby carcinogens to vaginal mesh - the list of lawsuits may finally outweigh profits.
Johnson & Johnson Acquires Synthes ... and This Incredible List of US FDA Violations! Johnson & Johnson spent $21.3 Billion to buy Sythes - with Synthes already having this very long list of FDA violations in U.S. West Chester, PA, United States facility.
What Contains Formaldehyde at 200 Times OSHA Safe Exposure Limit? Johnson & Johnson Baby Shampoo. Just how risky is it to use a baby shampoo that contains 200 times the OSHA safe exposure limit of formaldehyde on your child? Read this to find out.
Response to Bill Weldon About Bad Asbury Park Press Bill Weldon This is my interpretation and response to the letter sent by William Weldon, the $29 million CEO of Johnson and Johnson to the Asbury Park Press regarding their series on the dirty reality of Johnson and Johnson.
Is Johnson and Johnson Really Giving or Just Marketing? Building trust to sell harmful products and then recall defective risky products due to lack of quality control, withholding data from FDA, doctors and patients. We're supposed to trust JNJ? Ha!
Johnson & Johnson's William Weldon's $143.5 MILLION Retirement Package Okayyy, how about the high cost of healthcare? R&D? Yeah, right.
Johnson & Johnson Synthes U.S. FDA Violation List! Johnson & Johnson spent $21.3 Billion to buy Sythes - with Synthes already having a long list of FDA violations in U.S. West Chester, PA facility.
Johnson and Toxin, Er, Johnson & Johnson. Hm, Think I Had it Right the First Time Carcinogenic contaminants, carcinogens, allergens, potential neurological damage, bribery, class action lawsuits and recalls. Maybe it's time to stop giving Johnson and Johnson our money to pay their fines?